18 July 2024
Translation regulates gene expression and function. The study explores tRNA expression and translation in bovine tissues, having identified tissue-specific gene modulation and pausing sites. These were shown to influence translation and protein folding.
26 March 2024
A mouse model for MHC-I antigens isolation from specific cells in tumors. Antigen expression doesn't always match mRNA levels, suggesting new cancer vaccine targets & need for better prediction methods. Model works in various tissues & diseases.
26 March 2024
Existing RNA sequencing struggles with 3' phosphate ends. circAID-p-seq, a new method, solves this for phospho-RNA sequencing, like ribosome profiling. It allows studying ribosomal footprints and potentially other 3'-phosphate RNA molecules.
19 March 2024
3' modifications (phosphate, cyclic phosphate) on RNA (mRNA, rRNA, tRNA) are not dead ends but can be functional molecules in RNA metabolism & stress response. Standard RNA-seq misses them. tRNA fragments (tiRNAs) can be an example.
19 March 2024
Current methods miss details of active protein production. RiboLace isolates active ribosomes without tags, offering better data quality with less sample. It even captures disomes, potentially revealing new aspects of translation and disease links.
7 March 2024
Bovine study uses tRNA levels & ribosome profiling to link tRNA abundance with translation efficiency, revealing tissue-specific gene regulation and pausing sites impacting protein synthesis. Provides insights into codon optimality and tissue-specific pro
