Non-AUG start codons are used more than expected, leading to diverse protein forms with potentially new functions. New methods reveal these "alternative translation initiation sites" (aTIS).
AHARIBO sheds light on hidden functions of lncRNAs. It reveals ribosome-interacting lncRNAs and those producing small proteins in stem cells. This unveils functions beyond simple transcription for hundreds of lncRNAs.
A mouse model for MHC-I antigens isolation from specific cells in tumors. Antigen expression doesn't always match mRNA levels, suggesting new cancer vaccine targets & need for better prediction methods. Model works in various tissues & diseases.
Existing RNA sequencing struggles with 3' phosphate ends. circAID-p-seq, a new method, solves this for phospho-RNA sequencing, like ribosome profiling. It allows studying ribosomal footprints and potentially other 3'-phosphate RNA molecules.
RiboLace, a novel method using a unique puromycin derivative molecule, specifically captures actively translating ribosomes, enabling detailed analysis of genome-wide translation activity at single-nucleotide resolution.
Alex Jaeger, Postdoctoral Fellow at the Koch Institute for Integrative Cancer Research at the Massachusetts Institute of Technology, talks about translation analysis and its role in his cancer research
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