18 July 2024
Translation regulates gene expression and function. The study explores tRNA expression and translation in bovine tissues, having identified tissue-specific gene modulation and pausing sites. These were shown to influence translation and protein folding.
26 March 2024
AHARIBO sheds light on hidden functions of lncRNAs. It reveals ribosome-interacting lncRNAs and those producing small proteins in stem cells. This unveils functions beyond simple transcription for hundreds of lncRNAs.
26 March 2024
A mouse model for MHC-I antigens isolation from specific cells in tumors. Antigen expression doesn't always match mRNA levels, suggesting new cancer vaccine targets & need for better prediction methods. Model works in various tissues & diseases.
26 March 2024
Existing RNA sequencing struggles with 3' phosphate ends. circAID-p-seq, a new method, solves this for phospho-RNA sequencing, like ribosome profiling. It allows studying ribosomal footprints and potentially other 3'-phosphate RNA molecules.
26 March 2024
Non-AUG start codons are used more than expected, leading to diverse protein forms with potentially new functions. New methods reveal these "alternative translation initiation sites" (aTIS).
19 March 2024
Current methods miss details of active protein production. RiboLace isolates active ribosomes without tags, offering better data quality with less sample. It even captures disomes, potentially revealing new aspects of translation and disease links.
