18 July 2024
Translation regulates gene expression and function. The study explores tRNA expression and translation in bovine tissues, having identified tissue-specific gene modulation and pausing sites. These were shown to influence translation and protein folding.
26 March 2024
A mouse model for MHC-I antigens isolation from specific cells in tumors. Antigen expression doesn't always match mRNA levels, suggesting new cancer vaccine targets & need for better prediction methods. Model works in various tissues & diseases.
26 March 2024
RiboLace, a novel method using a unique puromycin derivative molecule, specifically captures actively translating ribosomes, enabling detailed analysis of genome-wide translation activity at single-nucleotide resolution.
19 March 2024
Current methods miss details of active protein production. RiboLace isolates active ribosomes without tags, offering better data quality with less sample. It even captures disomes, potentially revealing new aspects of translation and disease links.
8 March 2024
Nutrient levels control key RNA regulators (YTHDF proteins) via O-GlcNAc modification. This modifies YTHDF interaction with translation proteins and regulates stress granule assembly, impacting cellular stress response.
7 March 2024
Mouse embryo gene activation relies on translational regulation, not just gene transcription. Researchers identified key maternal factors activated during specific stages that are crucial for embryo development, potentially impacting fertility research.
