26 March 2024
RiboLace, a novel method using a unique puromycin derivative molecule, specifically captures actively translating ribosomes, enabling detailed analysis of genome-wide translation activity at single-nucleotide resolution.
19 March 2024
Current methods miss details of active protein production. RiboLace isolates active ribosomes without tags, offering better data quality with less sample. It even captures disomes, potentially revealing new aspects of translation and disease links.
1 January 2024
New puromycin-like probes explore protein interactions beyond ribosomes. These probes bind proteins involved in translation and might be used to map RNA associated with ribosomes. This opens doors to studying unknown translation control mechanisms.
