18 July 2024
Translation regulates gene expression and function. The study explores tRNA expression and translation in bovine tissues, having identified tissue-specific gene modulation and pausing sites. These were shown to influence translation and protein folding.
20 March 2024
It was inspiring being able to speak with Francesca Rapino, PI (Chercheur Qualifié-FNRS) and assistant professor at the Stem Cells-Cancer Signaling Laboratory at the University of Liège, Belgium, on her research with tRNAs, ribosomes and cancer.
20 March 2024
It was great being able to speak to Ribo-Omics Grant Challenge Winner Adrian Gabirel Torres, Research Associate at the Gene Translation Lab in the Institute for Research in Biomedicine in Barcelona, on the research he is doing with translation analysis
19 March 2024
3' modifications (phosphate, cyclic phosphate) on RNA (mRNA, rRNA, tRNA) are not dead ends but can be functional molecules in RNA metabolism & stress response. Standard RNA-seq misses them. tRNA fragments (tiRNAs) can be an example.
8 March 2024
Nutrient levels control key RNA regulators (YTHDF proteins) via O-GlcNAc modification. This modifies YTHDF interaction with translation proteins and regulates stress granule assembly, impacting cellular stress response.
8 March 2024
Nano-tRNAseq, a new method using nanopores, allows for simultaneous quantification of tRNA abundance and modifications in a single experiment. This overcomes limitations of previous methods and reveals details of tRNA populations in yeast under stress.
