18 July 2024
Translation regulates gene expression and function. The study explores tRNA expression and translation in bovine tissues, having identified tissue-specific gene modulation and pausing sites. These were shown to influence translation and protein folding.
26 March 2024
AHARIBO sheds light on hidden functions of lncRNAs. It reveals ribosome-interacting lncRNAs and those producing small proteins in stem cells. This unveils functions beyond simple transcription for hundreds of lncRNAs.
26 March 2024
A mouse model for MHC-I antigens isolation from specific cells in tumors. Antigen expression doesn't always match mRNA levels, suggesting new cancer vaccine targets & need for better prediction methods. Model works in various tissues & diseases.
8 March 2024
Nutrient levels control key RNA regulators (YTHDF proteins) via O-GlcNAc modification. This modifies YTHDF interaction with translation proteins and regulates stress granule assembly, impacting cellular stress response.
7 March 2024
Bovine study uses tRNA levels & ribosome profiling to link tRNA abundance with translation efficiency, revealing tissue-specific gene regulation and pausing sites impacting protein synthesis. Provides insights into codon optimality and tissue-specific pro
6 February 2024
Rett syndrome: Precise gene therapy (PHP.eB-iMecp2) in mice restores MeCP2 levels, improves function & lifespan. Safe in females, requires immunosuppression in males. #GeneTherapy #RettSyndrome
