22 July 2025
SLE impairs oocyte development by disrupting translation linked to reduced ac4C modification. Using single-cell omics, researchers showed that boosting ac4C with nicotinamide improves oocyte quality in SLE mice—highlighting a promising fertility strategy
19 February 2025
Ovarian endometriosis impacts oocyte quality, but the molecular mechanisms remain unclear. Using RiboLace pulldown, Diao et al reveal key translatomic and transcriptomic pathways—oxidative stress, meiosis, and spliceosome—linked to infertility
18 July 2024
Translation regulates gene expression and function. The study explores tRNA expression and translation in bovine tissues, having identified tissue-specific gene modulation and pausing sites. These were shown to influence translation and protein folding.
26 March 2024
AHARIBO sheds light on hidden functions of lncRNAs. It reveals ribosome-interacting lncRNAs and those producing small proteins in stem cells. This unveils functions beyond simple transcription for hundreds of lncRNAs.
26 March 2024
A mouse model for MHC-I antigens isolation from specific cells in tumors. Antigen expression doesn't always match mRNA levels, suggesting new cancer vaccine targets & need for better prediction methods. Model works in various tissues & diseases.
8 March 2024
Nutrient levels control key RNA regulators (YTHDF proteins) via O-GlcNAc modification. This modifies YTHDF interaction with translation proteins and regulates stress granule assembly, impacting cellular stress response.
