Short reviews

19 March 2024

Discover stories about translation that mRNA alone can’t tell

What happens when any of the rRNAs, 80 ribosomal proteins or about 150 non-ribosomal factors that are needed to bring ribosomes to life go wrong? Ribosomal dysregulation has been implicated in multiple diseases including cancer, autism, cystic fibrosis, Alzheimer’s disease and other neurodegenerative diseases. Researchers continue to seek new technologies that will help them dig deeper into how cells orchestrate active translation and how dysregulation influences disease. Isolated active ribosomes may reveal insights that might be obscured by the presence of inactive ribosomes. Ribosomes captured in action can provide access to underexplored translatome territory. With greater access, researchers may be able to uncover new insights about the factors that govern ribosomal function that cannot be identified from conventional mRNA analysis alone...