22 September 2025
Researchers identified METTL5 as a key driver of immune resistance in ovarian cancer. By altering rRNA methylation and ATF4 translation, METTL5 suppresses ferroptosis, reducing response to immunotherapy. Targeting this axis may enhance ICB efficacy.
29 July 2025
Large MAF transcription factors boost MYH4 expression and glycolytic metabolism in human and bovine muscle. This reveals a conserved role in fast-twitch fiber regulation, offering insight into MYH4 loss in larger mammals and potential muscle therapies.
22 July 2025
SLE impairs oocyte development by disrupting translation linked to reduced ac4C modification. Using single-cell omics, researchers showed that boosting ac4C with nicotinamide improves oocyte quality in SLE mice—highlighting a promising fertility strategy
10 March 2025
mRNA localization is key for cell migration. Boraas et al identify hundreds of FA-enriched mRNAs & reveal that G3BP1 RNPs regulate FA function. By enhancing FA protein mobility & size, G3BP1 promotes cell speed—unveiling a new role beyond stress response.
25 February 2025
HIV-1 gene expression is tightly regulated at multiple levels. Using RiboLace & proteomics, Labaronne et al reveal how translation & post-translational mechanisms shape infection. Notably, how uORF-derived peptides elicit immune responses.
19 February 2025
Ovarian endometriosis impacts oocyte quality, but the molecular mechanisms remain unclear. Using RiboLace pulldown, Diao et al reveal key translatomic and transcriptomic pathways—oxidative stress, meiosis, and spliceosome—linked to infertility
