9 February 2026
How do bacteria adapt to stress at the RNA level? This study maps dynamic RNA modifications in E. coli under oxidative and acid stress, revealing epitranscriptomic changes in mRNA, rRNA and tRNA that are crucial for translation control and survival.
19 January 2026
EZH2 drives prostate cancer progression by regulating m6A RNA modification. By stabilizing FOXA1, EZH2 boosts YTHDF1 expression, enhancing translation of METTL14 and WTAP and increasing global m6A. Targeting this axis suppresses tumor growth.
4 December 2025
Miluzio et al. reveal that eIF6 phosphorylation is essential for ribosome recycling after termination. Cellular stress disrupts this process, causing ribosomes to stall at stop codons.
22 September 2025
Researchers identified METTL5 as a key driver of immune resistance in ovarian cancer. By altering rRNA methylation and ATF4 translation, METTL5 suppresses ferroptosis, reducing response to immunotherapy. Targeting this axis may enhance ICB efficacy.
29 July 2025
Large MAF transcription factors boost MYH4 expression and glycolytic metabolism in human and bovine muscle. This reveals a conserved role in fast-twitch fiber regulation, offering insight into MYH4 loss in larger mammals and potential muscle therapies.
22 July 2025
SLE impairs oocyte development by disrupting translation linked to reduced ac4C modification. Using single-cell omics, researchers showed that boosting ac4C with nicotinamide improves oocyte quality in SLE mice—highlighting a promising fertility strategy
