Short reviews

19 March 2024

Phospho-RNA: The Hidden Layer of Transcriptomics

RNA molecules bear a hydroxyl (3’-OH), a phosphate (3’-P) or a cyclic phosphate (2’-3’cP) group at their 3’ end (Figure 1). 3′-P/2’-3’cP containing RNAs are generated by ribonucleases, toxin or ribozymes, but they are not mere side degradation products; rather they play a role in several biological processes, including RNA metabolism, rRNA and tRNA biogenesis, mRNA splicing, unfolding protein response and stress granules production...