AHARIBO sheds light on hidden functions of lncRNAs. It reveals ribosome-interacting lncRNAs and those producing small proteins in stem cells. This unveils functions beyond simple transcription for hundreds of lncRNAs.
A mouse model for MHC-I antigens isolation from specific cells in tumors. Antigen expression doesn't always match mRNA levels, suggesting new cancer vaccine targets & need for better prediction methods. Model works in various tissues & diseases.
Simone Sidoli, Assistant Professor and PI of Sidoli Lab at the Albert Einstein College of Medicine, Ullmann Research Center for Health Sciences in New York about his research in proteomics and specifically de novo protein synthesis
Alex Jaeger, Postdoctoral Fellow at the Koch Institute for Integrative Cancer Research at the Massachusetts Institute of Technology, talks about translation analysis and its role in his cancer research
Beyond RNA: Protein control is crucial for cells. New methods (ribosome profiling) reveal complex regulation of translation, including specialized ribosomes for specific protein production.
Transcriptome poorly predicts protein levels. New methods (Polysome Profiling, Ribosome Profiling) study ribosome-mRNA interactions to decipher translational control of gene expression.
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