tRNA sequencing
Total and ribo-embedded full-length tRNA capture
nano-tRNAseq
Quantification and detection of tRNA modifications
Studying the function of tRNAs in protein translation is fundamental for understanding their role in several cellular processes that can be impaired in various diseases. Immagina's nano-tRNAseq is the only technology that simultaneously quantifies full-length, native-state tRNAs and detects chemical modifications in a single experiment.
Ribo-tRNAseq
Detection and quantification of ribo-embedded tRNA
Once inaccessible, ribo-embedded tRNAs are now at reach with Immagina’s service. Ribo-tRNAseq leverages our RiboLace technology to pulldown ribosomes in active translation and our cutting-edge tRNA sequencing technology. Ribo-tRNAseq can be used for studying tRNAs actively engaged in translation, especially relevant in the fields of oncology and viral infections.
Key characteristics
| nano-tRNAseq | ribo-tRNAseq | |
|---|---|---|
| Captured tRNAs | Total tRNA population (full-length, fragments, etc) | tRNAs actively engaged in translation |
| Input |
|
|
| tRNA abundance detection? | ✓ | ✓ |
| tRNA modifications detection? | ✓ | ✓ |