8 March 2024

Non-coding RNAs in disease: from mechanisms to therapeutics

Lekka E, Hall J. Noncoding RNAs in disease. FEBS Lett. 2018 Sep;592(17):2884-2900. doi: 10.1002/1873-3468.13182. Epub 2018 Jul 20. PMID: 29972883; PMCID: PMC6174949.

Noncoding RNAs are emerging as potent and multifunctional regulators in all biological processes. In parallel, a rapidly growing number of studies has unravelled associations between aberrant noncoding RNA expression and human diseases. These associations have been extensively reviewed, often with the focus on a particular microRNA (miRNA) (family) or a selected disease/pathology. In this Mini‐Review, we highlight a selection of studies in order to demonstrate the wide‐scale involvement of miRNAs and long noncoding RNAs in the pathophysiology of three types of diseases: cancer, cardiovascular and neurological disorders. This research is opening new avenues to novel therapeutic approaches.

Keywords: long noncoding RNA, microRNA, noncoding RNA